12 Jan 2015
January 12, 2015

Stress before birth

By Jerrold S. Meyer
October 30th 2014

Stress seems to be everywhere we turn. Much of the daily news is stressful, whether it pertains to the recent Ebola outbreak in western Africa (and its subsequent entry into the United States), beheadings by the radical Islamic group called ISIS, or the economic doldrums that continue to plague much of the developed world. Moreover, we all experience frequent stress in our daily lives. Stress can come from your job, your family, a romantic relationship, personal attacks by way of social media, or, if you’re a student, your school performance. Counselors, psychotherapists, even self-help books and other materials may help us cope with stress, but these sources don’t usually give us very much information about what is actually happening to our brain and our body when we’re stressed.

If we think about it for a moment, it becomes clear that stress is not a recent phenomenon brought about by the features of contemporary western societies. Our hominid ancestors who evolved on the African savanna were surely stressed in the course of meeting their basic biological needs of finding food and water, acquiring shelter, and keeping safe from predators. Moreover, the principal brain and endocrine (i.e. hormonal) systems that underlie the cognitive, behavioral, and physiological responses to stress are found throughout the animal kingdom, indicating that these systems arose much earlier in evolutionary history than the appearance of the first hominids. So just what are these systems and how do they work?

Stress

Insert drawing of adrenal gland here with the following caption: Structure of the adrenal gland, showing the outer cortex and the inner medulla along with the hormones they secrete. Reproduced from Psychopharmacology. Drugs, the Brain, and Behavior, second edition, by Jerrold S. Meyer and Linda F. Quenzer. © Sinauer Associates. -

For many years, researchers focused on how stress, especially chronic stress, can damage the adult brain and body. More recently, however, it has become clear that stress may be particularly destructive during development. We now know, for example, that repeated childhood maltreatment and abuse increase the child’s vulnerability to a later onset of clinical depression or post-traumatic stress disorder. But stress can exert deleterious effects even earlier in development, namely during the prenatal period. Although the fetal adrenal glands begin to function before birth, it seems likely that stress is transmitted to the fetus mainly through maternal hormones such as cortisol. The placenta breaks down much of the mother’s cortisol before it reaches the fetus, but some of the hormone manages to get through. One example that shows how prenatal stress can adversely affect offspring development stems from a terrible ice storm that hit Québec Province in Canada in January of 1998. Three million people lost electrical power for up to 40 days, resulting in significant privation. David Laplante and colleagues at Douglas Hospital of McGill University later studied 89 five-and-a-half-year-old children whose mothers had been pregnant with them during the power outage. Children whose mothers endured the greatest hardship as a result of the storm scored noticeably lower in verbal IQ scores and in a vocabulary test than children whose mother experienced low or moderate hardship.

Pregnancy

Late pregnancy human fetus. Illustration by Bruce Blaus. Source: Blausen.com staff. “Blausen gallery 2014”. Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. CC-BY-3.0 via Wikimedia Commons.

While natural disasters like the Québec ice storm afford researchers the opportunity to investigate some of the deleterious effects of prenatal stress exposure, there are many limitations of such studies because the stress cannot be controlled experimentally and there are additional confounding variables such as differing postnatal experiences among the participants. To overcome some of these limitations and additionally permit a more detailed examination of behavioral, endocrine, and brain function than normally available with human participants, models of stress (including prenatal stress) have been developed for studying nonhuman primates such as rhesus monkeys. Offspring of rhesus monkeys exposed during mid-to-late pregnancy either to repeated mild stress or to pharmacological stimulation of cortisol release show behavioral and brain abnormalities that are still present at least several years later.

Young rhesus monkey, courtesy of author

Young rhesus monkey, courtesy of author

 

The implication of both the human and primate research is clear. We must pay closer attention to the well-being of pregnant women in order to minimize whatever life stresses can be controlled. By so doing, we can help newborn children begin life with better prospects for their future mental and physical health.



Jerrold S. Meyer, Ph.D., is Professor Emeritus in the Department of Psychological and Brain Sciences and former Director of the interdepartmental Neuroscience and Behavior Program at the University of Massachusetts – Amherst. He is Special Editions Editor of the journal Neurotoxicology and Teratology, the author with Linda Quenzer of Psychopharmacology: Drugs, the Brain, and Behavior, and the author or co-author of over 120 scientific papers and book chapters in such areas as neuropsychopharmacology and the hormonal responses to stress. He is the author of “Models of Stress in Nonhuman Primates and Their Relevance for Human Psychopathology and Endocrine Dysfunction” with Amanda F. Hamel (available to read for free for a limited time) in ILAR Journal.

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